The tradition of an annual discourse goes back to the Academy’s founding year, 1847, when Dr. John W. Francis delivered an oration to an audience of 2,500 people at the Broadway Tabernacle. At the Anniversary Discourse & Awards each fall, the Academy also recognizes five distinguished individuals for their leadership and contributions in their field. Following the Annual Meeting of the Voting Fellows on November 6, the 167th Anniversary Discourse was delivered by Claire Pomeroy, MD, MBA, President of the Albert and Mary Lasker Foundation, on “How Research Does and Should Inform Clinical Practice.” The Academy then honored the 2014 Academy Distinguished Award winners, who are esteemed leaders in academia, science, medicine, health policy, and public health.